The CRISP study is a blinded, placebo-controlled clinical trial comparing clozapine and risperidone administration in progressive MS patients. The study is based upon preclinical research showing that clozapine and risperidone were able to reduce brain inflammation in a model of MS. The aim of the CRISP trial is to assess the safety, acceptability, and potential efficacy of clozapine and risperidone in progressive MS patients.
Clozapine and risperidone have been used for decades to treat a variety of neurological disorders including schizophrenia, autism, and Parkinson’s disease and so are well-known drugs that have been administered to a large number of people. Interestingly, we discovered that the way in which these medicines may reduce disease in MS appears to be distinct from how they work in schizophrenia and Parkinson’s disease. In particular, our previous research indicates that the doses required are significantly lower than those used to treat schizophrenia, and we believe that these lower doses will make these medicines more suitable to MS patients.
The CRISP trial has begun recruiting participants through the Neurology Department at Wellington Hospital, and we aim to recruit a total of 36 participants with progressive MS. Additionally, participants must be between 18-70 years old and have an expanded disability status score of 3.5 to 7.0, inclusive.
For those participants enrolled in the study, after baseline clinical and laboratory investigations, participants will receive oral clozapine, risperidone, or a placebo. Because the trial is double-blinded, the participants and the trial staff will not know which medicine each participant is receiving. During the first week of treatment, participants are closely monitored and then, over the course of the 7-month participation in the trial, there will be regular clinical review and blood sampling.
This study has received approval from the Central Health and Disability Ethics Committee, reference (15/CEN/216) and the Standing Committee on Therapeutic Trials (15/SCOTT/177) and has been funded by the Ministry of Business, Innovation, and Employment and the Great New Zealand Trek Charitable Trust.
For more information about enrolling in the trial, contact Liz Goode the trial nurse (027 449 5843; email@example.com) and for general information about the trial, contact Anne La Flamme (firstname.lastname@example.org).
Book launch and fundraiser for Wellington MS Society
A FUNNY THING HAPPENED ON THE WAY TO THE NEUROLOGIST MULTIPLE SCLEROSIS BOOK LAUNCH FUNDRAISER
Shona Daubé faces the challenges of Multiple Sclerosis (MS) with humour and by writing a book – A Funny Thing Happened on the way to the Neurologist, a light-hearted take on living with MS. Shona wishes to increase understanding of living with MS and raise funds for the Wellington MS Society.
Two years ago Shona was diagnosed with MS. As a nurse, Shona was familiar with and feared the chronic, painful, and challenging aspects of MS. Shona discusses the background of her book, “To help face my fears, I viewed my new health challenges as funny stories. I turned these stories into amusing emails for my friends. I hoped the emails would help my friends understand what it’s like living with MS. I then thought it might be a good idea to gather these stories together in a book as a way of increasing understanding of MS as well as raising funds for the MS Society.”
Soon after diagnosis, at a workshop run by the Wellington MS Society Shona was introduced to Melbourne based Dr George Jelinek’s groundbreaking work in overcoming MS. Jelinek embraces traditional medicine as well as other approaches. He has developed a rigourously researched overcoming MS (OMS) recovery programme which promotes diet and lifestyle management. Jelinek’s programme has improved the health and lives of people with MS.
Shona comments on Jelinek’s programme, “Jelinek’s overcoming MS recovery programme – particularly diet, exercise and meditation, has significantly alleviated my MS condition and improved my overall well being. I want more people with MS to know about Jelinek’s work – there’s good information about the programme on the overcoming MS website.”
Shona lives in Carterton. From 12 December, A Funny Thing Happened on the way to the Neurologist will be on sale in Carterton at Toi Wairarapa – Heart of Arts, in Masterton at Hedley’s bookstore and through the Pink Cottage Publishing website.
A Funny Thing Happened on the way to the Neurologist is written by Shona Daubé and published by Pink Cottage Publishing. The book launch is at 1pm Sunday 11 December, Southern Cross Hotel, 39 Abel Smith Street, Wellington. The book price is $20. Proceeds from book sales will help fund Wellington Multiple Sclerosis Society’s field workers.
For Interviews – Shona Daube, email@example.com, Mobile +64 27 361 2182
For Photos and more information about the book – www.pinkcottagepublishing.co.nz
Interview with Dr George Jelinek – http://podcast.radionz.co.nz/aft/aft-20100202-1510-Tune_your_engine_-_multiple_sclerosis-048.mp3